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Description

Insulin receptor exon 11+/- is expressed in Zucker (fa/fa) rats, and chlorogenic acid modifies their plasma insulin and liver protein and DNA

The combination is generally well tolerated in clinical settings

Follow-up testing should be individualized

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations