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The CAT gene encodes catalase, a crucial scavenger of hydrogen peroxide in human erythrocytes, which is dependent on the availability of PPP-derived NADPH (58)
Both drugs commonly cause nausea, vomiting, and diarrhea
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Our results showed that HFD SAL mice express more ICAM-1 than ND SAL mice, and semaglutide treatment prevented the HFD-induced ICAM-1 expression in the brain microvessels, indicating that HFD induces an inflammatory environment that affects the integrity of the bloodbrain barrier [32, 33]
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