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These data confirm the pro-oxidative anti-cancer mechanism of pharmacologic AA and suggest that AA and GSH administered together provide no additional benefit compared with AA alone

Supplementary information This file contains Supplementary Fig

Importantly, hydrogen selenide and its activated form selenophosphate and other reactive low molecular mass (LMM) chemical species of Se are thought to be relevant to the majority of Se biological activity being metabolic precursors of selenoproteins (Loef et al., 2011