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These effects usually develop within the first few weeks of treatment but may diminish slightly over time as physiological adaptation occurs

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Proposed mechanisms include oxidative stress, mitochondrial dysfunction, dyslipidaemia, and genomic modulation of hypertrophic and fibrotic signalling pathways (70)

This leads to the next consideration are we witnessing the beginning of phenotype-guided sleep apnea therapy

Avoiding late meals and nighttime snacking is particularly important