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In addition, DESO is known to result in much less swelling than Aqualyx as well as less pain and faster results
Graham TE, Wilson BA "Five subjects performed 30 min of steady-state exercise (65% VO2max) on eight occasions while inspiring either 21 or 60% O2 in combination with 0, 2, 4, or 6% CO2
doi: 10.1080/19490976.2018.1465157
Those with more adipose tissue or slower initial response may benefit from increasing to 400-500mcg
The important clinical point is that these two pathways are synergistic
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