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26 Furthermore, DUL ameliorated LPS-induced oxidative stress in H9c2 myocardial cells, 22 and attenuated TNF--induced oxidative stress in human fibroblast-like synoviocytes, 28 because incretin-based therapy was found to exert antioxidant effects through the upregulation of renal Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), which augments the transcription of antioxidant enzymes that scavenge free radicals, indeed Nrf2 is a major regulator of oxidative state, enhancing cellular defenses against oxidative damage by upregulating the transcription of antioxidant enzymes

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[Abstract]2025 Apr 3;85(7):1253-1269

Furthermore, activity of the BER pathway was significantly increased in sALS patients (Kisby et al., 1997

Addition of glutamine to essential amino acids and carbohydrate does not enhance anabolism in young human males following exercise