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For their ligandin function, GSTs bind a wide range of compounds in a non-catalytic manner at so-called L-sites, which are often distinct from the active site

In the phase III clinical developmental programs of the DPP-4 inhibitors, non-inferiority was demonstrated after 1 and 2 years for these substances compared to sulfonylureas with respect to the glycaemic parameters HbA1c as well as fasting- and post-prandial plasma glucose concentrations

Currently, tirzepatide demonstrates superior outcomes compared to semaglutide in real-world practice, with 12-month weight reductions of 15.3% versus 8.3% respectively

By slowing digestion and influencing the brains appetite centers, semaglutide helps patients feel full earlier and stay full longer, leading to reduced food intake and meaningful weight loss

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