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Its more potent at the GIP receptor

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The mechanism is not fully understood, but it may relate to reduced caloric intake, altered glucose metabolism, or direct central nervous system effects

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McKay et al., 2014), all of which evidence suggests that GLP-1 RAs are associated with dehydration (Filippatos et al., 2014), which is consistent with the results of the two subsequent clinical trials (Winzeler et al., 2020