glp-1 oral receptor agonists are generating a great deal of excitement as a potential inflection point in diabetes and obesity care. Amid the enthusiasm, however, a quieter and clinically important issue is Clinical Capsules: Orforglipron Explained: A

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doi: 10.1007/s13205-021-02738-3 52 SebastiaoICandeiasESantosMSde OliveiraCRMoreiraPIDuarteAI

4a , one of the initial hits, inhibited GSTO1 enzyme activity with a half-maximal inhibitory concentration (IC 50 ) value of 3.1 M