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More recent studies of isolated acini from mouse and rat pancreas showed a small but dose dependent stimulation of amylase release comparable to that induced by VIP or secretin (54, 98)

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Regarding the proton leak ( Figure 8C ), a markedly higher OCR was observed at the end of the study in comparison to the other time points

STEP-3 (N=611) tested semaglutide combined with intensive behavioral therapy and found a 16.0% mean weight reduction at 68 weeks [4]

However, since factors other than glutathione contribute to acrolein resistance, the ALE strategy often yielded strains with reduced glutathione content (Nho et al., 2025)