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On the other hand, common neurological diseases, e.g., Alzheimers disease have pronounced both marked sex-dependency (Ferretti et al., 2018) and involvement in the BBB decline (Zenaro et al., 2017)

Primary Handling Editor: Christoph Schmitt, in collaboration with the Nature Metabolism editorial team

Statements Acknowledgments This work was supported through funding from Grants-in-Aid for Creative Scientific Research (to Masayuki Yamamoto) and Scientific Research (to Masayuki Yamamoto and Hozumi Motohashi) from the JSPS

PA affects people of all ages, but mostly those over 60

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