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In the landmark study that introduced it, published in Cell Metabolism (Lee et al., 2015), researchers showed that MOTS-c regulates insulin sensitivity and metabolic homeostasis through the AMPK pathway, and that treatment prevented diet-induced obesity and insulin resistance in animal models

There are no recognized adverse effects

The most common reason for coverage denial is the absence of a qualifying diagnosis beyond weight loss alone

Topics Pre-Release Starting July 9, 2024, the following topics are open for pre-release: A244-054 : Additive Manufacturing for High-Density Materials A244-055 : Advanced Pyrometallurgical Feedstock Processing to Produce Germanium Concentrates A244-P056 : Mobile Sustainment Tools Open Topic A244-P057 : Reverse Engineering Equipment Open Topic A244-P058 : Shop Tools and Enablers Open Topic A244-059 : Explosion Proof Collaborative Robots A244-060 : Affordable Alane Fuel A244-061 : Sensor Readout Integrated Circuit (ROIC) Design Blocks or Advanced Semiconductor Nodes A244-P062 : Uncooled Thermal Sensor Component Enhancement and Supply Chain Open Topic Full solicitation documents, instructions, and topic descriptions are available on the Defense SBIR/STTR Innovation Portal (DSIP)