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Through stimulation of pro-opiomelanocortin (POMC) neurons while simultaneously inhibiting neuropeptide Y/agouti-related peptide neurons in the arcuate nucleus, GLP-1 receptor agonism promotes satiety, reduces meal size, and decreases overall caloric intake [35]
The final sample sizes for each group were 15, 20, and 27 cases, respectively, which met the requirements
A second purification step was performed using a Superdex 75 column (GE Healthcare, Chicago, IL, USA) eluted with 20 mM TrisHCl buffer pH 7.4 and 150 mM NaCl
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