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Low appetite and unintentional under-eating
This isn't just inflation or trend, its a convergence of cost drivers - : 74% spike in $1M+ claims since 2021 - : providers are charging more : quietly adding 24% to premiums : GLP-1s and specialty drugs are reshaping budgets : demand is up, longer treatments, higher costs
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The serendipitous discovery of exendin-4 led to the development of exenatide immediate-release (exenatide IR, Byetta), a synthetic version of exendin-4 with C-terminal amidation to enhance its stability [ Figure 2 , Table 1 ], which became the first FDA-approved GLP-1RA in 2005 for the treatment of T2DM in adults [ Table 2 ]
Beyond that, degradation becomes measurable and progressive
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