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8.4 Pediatric Use The safety and effectiveness of RYBELSUS have not been established in pediatric patients

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For the underlying pharmacology and trial efficacy that justifies any spend on these drugs, see (Jastreboff et al., 2022) for tirzepatide SURMOUNT-1 and (Wilding et al., 2021) for semaglutide STEP-1

To mitigate these risks, some companies are exploring alternative delivery methods