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The titration schedule starts at 2 mg per week for 4 weeks, escalates to 4 mg for weeks 5 through 8, then to 8 mg for weeks 9 through 12, and reaches the 12 mg maintenance dose at week 13 (Jastreboff et al., NEJM 2023)
Molina P, Carrero JJ, Bover J, Chauveau P, Mazzaferro S, Torres PU, et al
Model 1 was adjusted for age and sex
Sure, they still cause weight loss at these doses, but not as much as the higher "weight loss" dose
Furthermore, in ECL1 of GCGR there are two glycine residues (G207 ECL1 , G219 ECL1 ) that disconnect the helical structure in the active state, whereas the G219 ECL1 is not conserved in GLP-1R and the helical conformation is relatively intact in this region of GLP-1R
