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Depending on the sample size, research topic and biological question that needs to be answered, sometimes internal validation or only geographic external validation may be sufficient (Ramspek et al
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Mingrone G, Greco AV, Capristo E, Benedetti G, Giancaterini A, De Gaetano A, Gasbarrini G: L-carnitine improves glucose disposal in type 2 diabetic patients
Gorman MJ
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