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Xiusheng Zhang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Together, our findings indicate that LaccID targets cleanly to the cell surface and is selectively active there, in contrast to APEX2 and HRP, which exhibit activity in ER and Golgi compartments

The appetite-suppressing effect of tesofensine was mostly reversed when co-administered with prazosin, a drug that blocks alpha-1 adrenoceptors, and partially blocked by SCH23390, a drug that blocks dopamine D1 receptors

Future directions include structural modifications to enhance brain targeting (e.g., curcumin nanocrystals, resveratrol phosphate prodrugs), identification of core pharmacophores and direct targets using chemical biology techniques (such as ABPP and CETSA), establishment of standardized evaluation systems for ferroptosis-inhibition potency to enable cross-comparison of EC 50 and therapeutic indices across consistent cell and animal models, and the development of combination strategies integrating natural compounds with synthetic inhibitors (e.g., low-dose Lip-1 with curcumin) to reduce dosage, minimize side effects, and enhance therapeutic efficacy

T cells: a growing universe of roles in neurodegenerative diseases