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Consistently, as evident from increased PSD95- and MAP2-positive puncta, we also observed an increase in the colocalization of postsynaptic PSD95 and neuronal marker MAP2 in the hippocampi of Hex-fed 5XFAD mice as compared with that in vehicle-fed 5XFAD mice (Figure 5, C and E, and Supplemental Figure 2B)

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