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This pathway not only suppresses CD8T cell infiltration but also downregulates major histocompatibility complex class I (MHC I) expression and inhibits interferon-gamma (IFN-) signaling, thereby undermining antitumor immune responses at multiple levels [85]
Notably, the Na + -coordinating residues and the gating residues are separated by a helical break near G36 on TM1 and we speculate that Na + -binding may stabilise a conformation in which the extracellular gate can form
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