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Moreover, as seen in HepaRG cells, higher cyclosporine concentrations (50 M) are associated with irreversible alterations in efflux and uptake activities, which ultimately resulted in the constriction of bile canaliculi and disorganization of the pericanalicular F-actin microfilaments (Sharanek et al., 2014)

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Of note, it is a common practice to combine nebulised heparin, N-acetylcysteine, budesonide and ipratropium bromide in smoke inhalation-induced lung injury, which shared similar pathophysiology with COVID-19 pneumonia, including diffuse alveolar damage, hyperinflammation, coagulopathy, hyaline membranes and microvascular thrombosis [30,31,32,33]

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