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Key considerations include: Increased risk of hypoglycemia when used with insulin or sulfonylureas Possible need for INR monitoring if taking warfarin Limited clinically relevant effects on most other oral medications Understanding what's normal during the initial treatment period helps set realistic expectations and identify situations requiring medical attention

Revised: 6/2026 Full Prescribing Information WARNING: RISK OF THYROID C-CELL TUMORS In rodents, semaglutide causes dose-dependent and treatment-duration-dependent thyroid C-cell tumors at clinically relevant exposures

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10.1083/jcb.133.5.1083 24 LilligC