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Oxidative stress can damage cells and proteins (including those that make up DNA), causing diseases and even killing the cells

At the clinical strategy level, the establishment of quantifiable metabolic readouts, such as the Kyn/Trp ratio, the expression of key metabolic enzymes or transporters, and the proportions of signaling metabolites, combined with stratified interventions based on disease stage and tissue involvement, may help further promote tissue repair and restoration of immune homeostasis while suppressing inflammatory responses, thereby enabling treatment strategies for autoimmune diseases with greater long-term benefit (139)

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Study of schizophrenic patients and healthy controls in the Arab population from Syria found a strong association between C677T and schizophrenia, which showed higher variant T allele frequency in the patients group

Yuan et al., A flame retardant and flexible gel polymer electrolytes for high temperature lithium metal batteries