The field of peptide therapy has a history of issues and abuses of medical power, such as the Verkow triad, and it is essential to be cautious when introducing new interventions to patients, with the primary goal of doing no harm 10s
Several decisions were close, and the committee heard substantial disagreement about chemical characterization, peptide-related impurities, immunogenicity, carcinogenicity signals or uncertainty, the limited quantity and quality of human evidence, and whether existing FDA-approved therapies already address the proposed uses
Whether these effects translate reliably to in vivo neuromuscular junction models is still an active area of investigation
Diabetes Care 40 , 6976 (2017)
Since NADPH is needed to drive redox reactions as a strong reducing agent, the NADP + /NADPH ratio is kept very low