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IDO and interferon-alpha-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity
The synthetic transition solved the standardization problem a defined sequence can be made reproducibly and characterized precisely by mass spectrometry and HPLC but it did not, by itself, resolve the deeper questions of whether these peptides truly reach specific tissues, truly enter nuclei at physiologically relevant concentrations, and truly regulate genes in a way that produces meaningful clinical benefit
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Knutson MD
Aging neutrophils, in addition to being smaller in size and containing fewer granules (31), exhibit the enhanced pro-inflammatory activity but have impaired adhesion and phagocytic functions (32, 33)
