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Diabetes & Metabolism, 2003, 29(4), pp.6S117-6S120 [13] Lalau, J., Mourlhon, C., Bergeret, A
In our review of the literature, we did not find any prospective clinical studies with sufficient evidence to support the use of metformin, melatonin, tranexamic acid, vitamins A, C, D, E, niacinamide, or zinc in the treatment of skin aging
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Brestoff, J
Direct and indirect biomarkers are used as follows: Lipid peroxidation: Malondialdehyde (MDA) is measured via the Thiobarbituric Acid-Reactive Substances (TBARS) assay, while F 2 -isoprostanes (stable end-products of arachidonic acid oxidation) are quantified by gas or liquid chromatography-massmass spectrometry (HPLC/MS-MS) for high specificity (Sabitha et al., 2024)
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