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Older GH secretagogues tended to drag the hypothalamic-pituitary-adrenal axis along with the GH axis, raising stress hormones as an off-target consequence

152 Other central nervous system stimulants elevate synaptic dopamine via mechanisms such as dopamine reuptake inhibition, reversal of dopamine transporter function, and promotion of dopamine release

Epub 2009 Dec 16

Tanelian et al., 2023

The most common exclusion criteria included major depressive disorder, uncontrolled hypertension, malignant neoplasms and liver disease, with the latter for tirzepatide only