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The retatrutide and orforglipron datasets support adding those therapies to formulary pipelines, though with different timelines: orforglipron is already on pharmacy shelves at $149 per month for self-pay patients, while retatrutide awaits an NDA filing and is expected to reach approval in 2027 or 2028
The populations that would benefit most havent even been included in the trials in significant numbers, Albert says
The problem emerged during polypharmacy
Hormonal changes, reduced muscle mass, insulin resistance, stress, and lifestyle factors can all contribute to increased abdominal fat storage
