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Factoring in tumor biomarkers when selecting ADC payloads may also play a role in enhancing therapeutic precision
That one substitution has been reported to increase resistance to enzymatic degradation and to raise potency in rodent models relative to the parent hexapeptide
10.1016/j.mito.2011.06.013 Mitochondrion 180 van ZandwijkN.DalesioO.PastorinoU.de VriesNvan TinterenH
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