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Editors ManzoF.MutalikS., 2013

The general healing process can be divided into three overlapping phases: (1) inflammatory phase (days 15), (2) repair/proliferative phase (days 514) and (3) remodelling phase (days 1490+) (Hope and Saxby 2007)

Moreover, an open, single-arm, first-in-human trial of PU-H71 in patients with advanced solid tumors showed that the incidence of grade 2 adverse events such as common nausea, headache, and fatigue was extremely low, and only one patient exhibited a grade 3 adverse event (vomiting) that could be related to PU-H71

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The mechanism involves deactivating the tyrosinase enzyme responsible for skin pigmentation