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Inaba R, Vujakovic S, Bergstrom K
GLP-1 medications like semaglutide and tirzepatide have demonstrated impressive efficacy in clinical trials, facilitating weight loss of approximately 10% to over 17% of total body weight
5256,59,60 Weight gain after discontinuation of a GLP-1 RA creates a theoretical risk of hypertrophy of mature adipocytes in grafted millifat and microfat, potentially causing excessive volumization
The dose escalation in days 16-30 is designed to reinforce the signaling pathways activated in Phase 1
Cloning the GLP-1 receptor Another important chapter was opened up for understanding the biology of GLP-1 by the cloning of the GLP-1 receptor
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