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Central Illustration Abstract Background The glucagon-like peptide-1 receptor agonist, semaglutide, improved health status and reduced body weight in patients with obesity-related heart failure (HF) with preserved ejection fraction (HFpEF) in the STEP-HFpEF (Semaglutide Treatment Effect in People with Obesity and HFpEF) program
If Youre Taking (or Considering) a GLP-1 Medication Heres what I recommend: Talk to your doctor about how the medication could impact your muscle and bone health
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The clinical question is whether MET-097i's convenience advantage can match semaglutide's efficacy and safety in Phase 3 trials
Importantly, a GLP-1 receptor antagonist blocked these response patterns, supporting the idea that these effects were indeed mediated by GLP-1 receptors (ten Kulve et al., 2017)
