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Overall, the authors suggested complex gene-environment interactions at the basis of the maternal susceptibility for the birth of a child with DS, and many others have subsequently measured or estimated biomarkers of one-carbon metabolism in MDS and control mothers, including plasma hcy, plasma or serum folate, vitamin B6 and/or vitamin B12, red blood cell (RBC) folate, and related micronutrients, searching for association with the genetic polymorphisms of folate pathway genes (Table 3)
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