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Standard aseptic technique applies during reconstitution, and contact with reducing-agent contaminants (DTT, beta-mercaptoethanol residue on glassware) should be avoided
Common experiences after the first injection include: Mild soreness or redness at the injection site (usually resolves within 12 days) Slight improvement in energy levels or mood No immediate noticeable change (particularly common if deficiency is severe) Rarely, mild side effects such as headache or dizziness Some patients report their urine becoming brighter or more intensely coloured following injection, which occurs because excess B12 is excreted renally
Changes in smell or unusual odours
doi: 10.3389/fcell.2020.551681 242 XiaoJWangRZhouWCaiXYeZ
In the presence of neurological symptoms, following daily treatment, injections up to weekly or biweekly are indicated for six months before initiating monthly IM injections
