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Studies have shown that IECs in IBD patients exhibit decreased GPX4 expression and increased susceptibility to lipid peroxidation, leading to ferroptotic cell death, barrier dysfunction, and increased gut permeability (168, 169)

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Together, GGT and ChaC1 regulate both intracellular and extracellular GSH degradation, emerging as promising prognostic markers and therapeutic targets for specific types of tumor such as liver cancer (172,173), breast cancer (74) and so on

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Out too long: If the pen has been out of the fridge for more than 28 days, its no longer safe