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Some people naturally have variations in receptor sensitivity or downstream signalling pathways that reduce drug effectiveness

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The conservative shelf life for reconstituted peptide is 28 days, though some protocols document stability up to 60 days when stored properly

Nonetheless, these severe side effects were also present in some people who took GLP-1s and tirzepatide for weight loss and were not suffering from type 2 diabetes

(2) Preparation of compound 4: activating the compound 3, and carrying out acylation coupling reaction on the activated compound and Arg34GLP-1 (9-37) terminal amino group in the compound 2 under the action of a condensation reagent and alkali to obtain a compound 4