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Always rotate injection sites to prevent tissue damage and increase comfort

This occurs because the underlying biological drivers of obesity, hormonal setpoints, metabolic adaptation, and appetite regulation, reassert themselves once the pharmacological intervention is removed

Compounded semaglutide and tirzepatide are not FDA-approved medications

Severe Gastrointestinal Disease People with inflammatory bowel disease, Crohns disease, or other serious GI conditions were largely excluded from retatrutide trials

A practical rotation schedule: abdomen during weeks 1-4, upper thigh during weeks 5-8, upper arm during weeks 9-12, then back to abdomen for maintenance