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DESTINY-Lung01, a phase II trial evaluating the efficacy of T-DXd in pre-treated NSCLC harboring HER2 molecular alterations includes two cohorts of patients: The HER2 -mutant cohort included 91 patients, showing an ORR of 55%, a median DoR of 9.3 months (95% CI, 5.7 to 14.7) and medians PFS and OS of 8.2 (95% CI, 6.0 to 11.9) and 17.8 months (95% CI, 13.8 to 22.1), respectively [4,33,34]
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Preliminary findings from these ongoing trials have shown that utilizing glutathione precursors (like high-dose N-acetylcysteine) successfully restores these brain glutathione levels, reduces markers of central nervous system oxidative stress, and significantly ameliorates the clinical symptoms of ME/CFS
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