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This decline accelerates oxidative stress, inflammation, and disease risk [2]
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The inhibition of xanthine oxidase in vitro by trace amounts of I-ascorbic acid
J Neurochem 16: 14091416
When a cell over-expresses NNMT, it does two costly things at once: it burns through methyl-donor capacity, and it diverts nicotinamide away from NAD+ regeneration into an inert metabolite (1-methylnicotinamide) that gets excreted
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