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Fifth, hormonal measurements were performed while patients remained on semaglutide, which may have influenced endogenous GLP-1 levels through feedback inhibition (in one sample)
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37 , W202W208 (2009)
In the SURMOUNT5 trial, participants lost an average of 20.2 % of their baseline body weight over 72 weeks with tirzepatide, with a greater proportion achieving weight-loss thresholds of 1525 % compared with semaglutide
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