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Interestingly, RipAYs enzymatic activity requires the activation by eukaryotic thioredoxins, which are highly abundant in plants during pathogen infection (Tada et al., 2008)

Pharmacol Ther 63:135161 Rachmilewitz D, Karmeli F, Okon E (1995) Sulfhydryl blocker-induced rat colonic inflammation is ameliorated by inhibition of nitric oxide synthase