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Someone starting at BMI 32 might lose a higher percentage of their body weight than someone starting at BMI 42, even though the person at BMI 42 loses more total kilograms

This would be in line with preclinical observations that incretin receptor expression is down-regulated by exposure to high glucose, and improves once normoglycaemia is restored (48), and that dys-regulation of glycaemic control in otherwise healthy humans leads to impaired incretin actions (49)

Our findings suggest that GSH depletion induces ferroptosis, autophagy, and SIPS