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Contact your GP for B12 testing if you have: Symptoms suggesting deficiency (persistent fatigue, pins and needles, memory problems, glossitis) Risk factors for deficiency (vegan diet, gastric surgery, long-term metformin or proton pump inhibitor use) [1] [4] Concerns about whether your current supplementation dose is appropriate Underlying conditions affecting B12 metabolism (kidney disease, liver disease) Unexplained high B12 levels on a blood test when not taking supplements Routine monitoring is essential for patients receiving therapeutic B12 injections

Exposure to fatty acids aggregates lipid accumulation and accelerates tubular cell necroptosis

doi: 10.1038/s41392-021-00827-6 88 NgoBKimEOsorio-VasquezVDollSBustraanSLiangRJet al