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This process may take several months, as dose changes require time to stabilize in the body and for symptoms to improve

However, supplementation may be beneficial for enhanced effects

Associated epilepsy managed with AEDs

Placebo-controlled studies examining these agents have failed to show a consistent beneficial effect on Peyronies disease, with the exception of para-aminobenzoate, which may decrease plaque size and curvature, and acetyl-L-carnitine, which may reduce erectile pain and inhibit disease progression

However, the drugs with the greatest risk (odds ratio) of discontinuation due to adverse events were semaglutide (Odds ratio 2.45), naltrexone-bupropion (2.69), and phentermine-topiramate (2.40)