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In both trials, the most common adverse events were nausea, vomiting, diarrhea, and constipation
Wegovy tends to result in greater weight loss than metformin
Spector AC, Travers SP
The increase in appetite might be related to the agonistic effect of Ipamorelin on ghrelin receptors which may stimulate hunger, as well as the increase in insulin production observed in animal experiments
But this mechanism depends on an individual's gut microbiome, habitual diet, and the dose and form of carnitine
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