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J Biol Chem 247(13):42484252 Kirabo A, Fontana V, de Faria APC, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen S, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J, Harrison DG (2014) DC isoketal-modified proteins activate T cells and promote hypertension

Phase 1: initiation and early escalation (weeks 1 to 8) During the first weeks, heart rate changes are generally minimal at starting doses

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