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The agency has logged 990 reports of adverse events associated with compounded semaglutide and more than 730 associated with compounded tirzepatide, and it cautions that adverse-event reporting is voluntary and almost certainly undercounts the real total

There are also motility alterations, such as diarrhea explained by the rapid colonic transit, as GLP1 activates intrinsic afferent neurons containing calcitonin gene-related peptide that favors the frequency of peristaltic contractions (158) or constipation due to mechanisms dependent on nitric oxide and AMPc/PKA that reduces colon contractility (159)

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While not suitable for every patient, this therapy offers clear advantages for those seeking convenience and effectiveness

The role of gastrointestinal vagal afferents in the control of food intake: current prospects