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This study offers a practical guideline for surgeons managing patients on GLP-1 agonists in the perioperative period for lower extremity THA and TKA procedures
In terms of technical pathways, fluorescent/radiolabeled tracers targeting activated Caspase-3/9 can be designed to monitor apoptosis, specific probes combining p-MLKL or its downstream membrane conformational changes can be developed to label necroptosis, and probes recognizing GSDMD-N terminal or IL-1 enrichment can reflect pyroptosis hotspots, with longitudinal follow-up in animal models and early clinical studies to depict the time trajectory of switching from apoptosis to lytic PCD, providing a dynamic visualization of PCD window for personalized interventions (315)
It is also used to address low sperm activity and in cases of weakened immune systems
Instead of mimicking GHRH, ipamorelin activates ghrelin receptors, the same receptors that signal hunger and also stimulate GH release
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