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GSH is also capable of reducing other ROS through nonenzymatic reactions 1 , and these reactions result in significant degradation of GSH 26

For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

PubMed Central, doi:10.1111/andr.12498

6.2 GLP-1 role in metabolic stability GLP-1 plays a key role in maintaining metabolic stability, particularly in critical conditions such as sepsis, where the organism often enters a catabolic state with disturbed glycemic regulation

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