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The pathogen's attempt to counter phosphite's growth-inhibitory effectsthrough upregulation of alternate bioenergetics pathways (amino acid catabolism and -oxidation of fatty acids), mitochondrial translation and translocation machinery, peroxisomal proteins, and antioxidantsappears ineffective

On the basis of results of the most recent CVOTs (DAPA-HF, DAPA-CKD, EMPEROR-R), the FDA has approved dapagliflozin (2020) and empagliflozin (2021) to reduce risk for CV death and HF hospitalization in adults with HF and reduced ejection fraction regardless of whether they have diabetes [24, 25]

It is a game changer

A pulse that rises and falls resembles the endogenous pattern more closely than a chronically elevated plateau

This article was written by Amanda Ciprich, MS, RD